Nagoya Univ. Developed by Dr. Hajime Fujisawa, Nagoya University in 1997. A neomycin selection cassette was inserted into a fragment of the sequence encoding the a1 domain of the protein. ICR background. herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, SV40 poly A, mouse C57BL/6 Neuropilin-1 genomic DNA 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Neuron, 19, 995-1005 (1997). ICR.Cg-Nrp1<tm1Hfu>/HfuRbrc 特になし。 true <a href='https://brc.riken.jp/mus/pcr01058'>Genotyping protocol -PCR-</a> Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] このマウス系統は、1997年に名古屋大学大学院理学研究科の藤澤肇先生と大学共同利用機関法人自然科学研究機構生理学研究所の八木健先生によって開発された。 Cardiovascular Research In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Neuron, 19, 995-1005 (1997). 藤澤　肇 Hematological Research C（3〜6か月） ICR-Nrp1<tmHfu> ICR-Nrp1<tmHfu> Developmental Biology Research ICR.Cg-Nrp1<tm1Hfu>. Neuropilin-1 (Nrp1) is a type I membrane protein and has been shown to function as a receptor for semaphorin III/D. Nrp1 homozygous mutant mice were embryonic lethal, and show severe abnormalities in the trajectory of the cranial and spinal efferent fibers of the parasympathetic nerve system. 名古屋大学 Hajime FUJISAWA 神経線維の投射異常、神経細胞の移動異常、心臓・血管系の形成異常があり、神経形成、血管形成の制御、免疫系の解析に適す。ホモ欠損個体は胎生11日までに致死。 Neurobiology Research Immunology and Inflammation Research RBRC01058 C (3-6 months) Sibling Mating (Heterozygote x Wild-type, Heterozygote) or Cross to ICR (Heterozygote x Slc:ICR) Embryonic lethality (Homozygous). Homozygote mutant mice die up to E11. covid19_infection ICR-Nrp1tmHfu Sibling Mating (Heterozygote x Wild-type, Heterozygote) or Cross to ICR (Heterozygote x Slc:ICR)Embryonic lethality (Homozygous). Homozygote mutant mice die up to E11.